Iron (Thyroid Support)
An essential mineral required for thyroid peroxidase enzyme function and thyroid hormone synthesis.
Also known as: Ferrous Bisglycinate • Iron Bisglycinate • Fe
Overview
Iron is a critical cofactor for thyroid peroxidase (TPO), the enzyme responsible for iodinating tyrosine residues to form thyroid hormones. Iron deficiency impairs thyroid hormone synthesis and is a common but overlooked cause of persistent hypothyroid symptoms. Women of reproductive age are particularly at risk for both iron and thyroid deficiency.
Key Benefits
TPO Enzyme Function
Iron is a cofactor for thyroid peroxidase, essential for thyroid hormone synthesis.
Thyroid Hormone Production
Iron deficiency directly impairs the thyroid's ability to produce T3 and T4.
Oxygen Transport
Hemoglobin requires iron to deliver oxygen to all tissues including the thyroid.
Energy Production
Iron is essential for mitochondrial energy production and cytochrome enzymes.
Dosage & How to Take
18-36 mg elemental iron daily (if deficient).
| Purpose | Dose | Notes |
|---|---|---|
| Mild deficiency | 18-25 mg/day | Bisglycinate form |
| Moderate deficiency | 25-36 mg/day | With vitamin C for absorption |
Best Time to Take
On empty stomach or with vitamin C.
With or Without Food
Best on empty stomach; take with vitamin C to enhance absorption.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Iron Bisglycinate | High | Gentle on stomach, well-absorbed | Chelated form with fewer GI side effects. |
| Ferrous Sulfate | Moderate | Budget option | More GI side effects. |
Side Effects & Safety
Common
- Constipation
- Dark stools
- Nausea
Rare
- Iron overload (hemochromatosis)
Contraindications
- Hemochromatosis
- Iron overload conditions
- Do not supplement without testing
Interactions
Iron reduces levothyroxine absorption; separate by 4 hours.
Calcium inhibits iron absorption; separate doses.
Scientific Research
Iron deficiency and thyroid function
Studies showed iron deficiency impairs thyroid hormone synthesis and that iron supplementation improves thyroid function in iron-deficient women.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.