Hesperidin
Citrus flavonoid for vascular health and inflammation
Also known as: Citrus Bioflavonoid • Hesperitin glycoside
Overview
Hesperidin is a flavanone glycoside found abundantly in citrus fruits, particularly in the peel and white pith of oranges. It is widely prescribed in Europe (often combined with diosmin) for chronic venous insufficiency and hemorrhoids. Beyond vascular health, hesperidin demonstrates significant anti-inflammatory and antioxidant properties, with emerging research in blood pressure regulation, cholesterol management, and blood sugar control. Hesperidin's bioavailability can be limited in its natural form, but micronized formulations show improved absorption.
Key Benefits
Vascular Health
Strengthens blood vessel walls, improves venous tone, and reduces capillary permeability.
Anti-Inflammatory
Inhibits multiple inflammatory pathways including NF-kB and COX-2.
Blood Pressure Support
Clinical studies show it can modestly reduce blood pressure.
Dosage & How to Take
500-1000 mg per day
| Purpose | Dose | Notes |
|---|---|---|
| Vascular health | 500-1000 mg/day | Often combined with diosmin |
| General antioxidant | 250-500 mg/day | Standard dose |
Best Time to Take
With meals
With or Without Food
Yes
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Micronized Hesperidin | High | Vascular conditions | Improved absorption |
| Hesperidin-Diosmin Complex | High | Venous insufficiency | Most studied formulation |
Side Effects & Safety
Common
- Mild stomach upset
Rare
- Allergic reaction (citrus allergy)
Contraindications
- Citrus allergy
Interactions
May have mild antiplatelet effects
May affect drug metabolism
Scientific Research
Hesperidin and Venous Insufficiency
Diosmin-hesperidin combination reduced leg swelling by 40-50%
Food Sources
Products With Hesperidin
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.