FoodState Folate

A naturally-derived form of folate from whole foods for optimal bioavailability.

Also known as: Folate (Food-Based) • Saccharomyces cerevisiae Folate

other Names
Folate (Food-Based), Whole-Food Folate
primary Benefits
Cell growth, DNA synthesis, prevention of neural tube defects
common Dose
400-800 mcg DFE per day
best Form
FoodState or L-5-MTHF
timing
Can be taken anytime
safety Rating
High safety profile

Overview

FoodState Folate is a form of Vitamin B9 derived from whole foods, typically broccoli, and delivered within a food matrix. This is distinct from folic acid, the synthetic form, and is believed to be more easily utilized by the body, especially for those with MTHFR gene mutations.

Key Benefits

Supports Healthy Fetal Development

Crucial for pregnant women to prevent neural tube defects in the developing fetus.

Essential for DNA Synthesis and Repair

Folate is a key component in the creation and repair of DNA, supporting healthy cell division and growth.

Aids in Red Blood Cell Formation

Works with Vitamin B12 to help create healthy red blood cells and prevent certain types of anemia.

Dosage & How to Take

The Recommended Dietary Allowance (RDA) is given in Dietary Folate Equivalents (DFE).

PurposeDoseNotes
General Adult Health400 mcg DFEDaily requirement for most adults.
Pregnancy600-800 mcg DFEHigher dose recommended before and during pregnancy.

Best Time to Take

Can be taken with or without food at any time of day.

With or Without Food

Not required, can be taken on an empty stomach.

Forms & Bioavailability

FormAbsorptionBest ForNotes
FoodState FolateHighNatural form, good for MTHFR variantsDerived from whole foods like broccoli.
Folic AcidHighFortification and supplementsSynthetic form that must be converted by the body.
L-5-MTHFVery HighDirectly usable active formBypasses the MTHFR conversion step.

Side Effects & Safety

Common

  • None at recommended doses.

Rare

  • High doses of folic acid (not folate) can mask a Vitamin B12 deficiency.

Contraindications

  • None known for natural folate from food.

Interactions

MethotrexateImportant

This medication can interfere with folate metabolism.

Scientific Research

2014The Journal of Clinical Investigation

Folate and Folic Acid in Health and Disease

Folate is essential for numerous bodily functions, and its deficiency can lead to a range of health problems. Natural folates and folic acid have different metabolic pathways.

Food Sources

Broccoli
Lentils
Spinach
Asparagus

Frequently Asked Questions

Medical Disclaimer

This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.