DAO (Diamine Oxidase)

An enzyme that helps to break down histamine from food, relieving symptoms of histamine intolerance.

Also known as: Histaminase

other Names
Histaminase
primary Benefits
Relieves symptoms of histamine intolerance
common Dose
1-2 capsules before meals
best Form
Enteric-coated capsules
timing
15-30 minutes before meals
safety Rating
Generally safe and well-tolerated.

Overview

Diamine Oxidase (DAO) is an enzyme that is naturally produced in the body and is responsible for breaking down histamine from the foods we eat. A deficiency in DAO can lead to histamine intolerance, a condition that can cause a variety of symptoms. DAO supplements can help to support the breakdown of dietary histamine.

Key Benefits

Alleviates Histamine Intolerance Symptoms

The primary benefit of DAO supplementation is the reduction of symptoms associated with histamine intolerance, such as headaches, digestive issues, and skin problems.

Supports Healthy Histamine Metabolism

Provides the body with the necessary enzyme to break down histamine from food, preventing its accumulation and subsequent adverse reactions.

Dosage & How to Take

DAO supplements should be taken 15-30 minutes before consuming histamine-rich foods. The typical dose is 1-2 capsules per meal.

PurposeDoseNotes

Best Time to Take

Must be taken before meals to be effective.

With or Without Food

Taken before meals, not with them.

Forms & Bioavailability

FormAbsorptionBest ForNotes
Enteric-Coated CapsulesHighProtection from stomach acidThe enteric coating ensures that the enzyme is released in the small intestine where it is needed.

Side Effects & Safety

Common

    Rare

      Contraindications

        Interactions

        Certain medications (e.g., some antidepressants, NSAIDs)Moderate

        Can inhibit the body's own DAO production, potentially worsening histamine intolerance.

        Scientific Research

        2019Clinical and Translational Allergy

        Diamine oxidase supplementation improves symptoms in patients with histamine intolerance

        DAO supplementation led to a significant improvement in symptoms in patients with histamine intolerance.

        Food Sources

        Products With DAO (Diamine Oxidase)

        1 product in our database contains this ingredient

        Frequently Asked Questions

        Medical Disclaimer

        This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.