Citrulline DL-Malate
An amino acid compound that boosts nitric oxide, enhances performance, and reduces muscle soreness.
Also known as: Citrulline Malate 2:1
Overview
Citrulline DL-Malate is a dietary supplement compound consisting of the amino acid L-Citrulline bonded to DL-Malate, an intermediate in the Krebs cycle. It is primarily used to increase nitric oxide production, which improves blood flow, and to help clear ammonia from the blood, reducing exercise-induced fatigue. The malate component may also contribute to energy production.
Key Benefits
Boosts Nitric Oxide
L-Citrulline is efficiently converted to L-Arginine in the kidneys, leading to a significant increase in nitric oxide (NO) levels.
Enhances Athletic Performance
Studies show it can increase repetitions performed, reduce the rating of perceived exertion, and increase power output.
Reduces Muscle Soreness
Significantly decreases post-exercise muscle soreness (DOMS) by up to 40% in some studies.
Aids in Ammonia Clearance
Plays a key role in the urea cycle, helping to remove ammonia, a byproduct of exercise that contributes to fatigue.
Dosage & How to Take
The clinically effective dose for performance benefits is 6-8 grams of Citrulline Malate.
| Purpose | Dose | Notes |
|---|---|---|
| Endurance & Performance | 6,000 - 8,000 mg | Take 30-60 minutes prior to training. Ensure the product specifies a 2:1 ratio of Citrulline to Malate. |
| General Health | 3,000 mg | Lower doses can be used for cardiovascular health benefits, but performance effects are seen at higher doses. |
Best Time to Take
For athletic performance, consume 30-60 minutes before your workout.
With or Without Food
Can be taken with or without food, but may absorb slightly faster on an empty stomach.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Citrulline DL-Malate | High | Athletic performance and energy production. | Typically found in a 2:1 or 1:1 ratio. The 2:1 ratio is more common in sports supplements. |
| L-Citrulline (Free Form) | High | Purely for nitric oxide benefits without the malate. | Requires a lower dose (3-5 grams) compared to Citrulline Malate. |
Side Effects & Safety
Common
- Generally very well-tolerated. Some individuals may experience mild stomach discomfort at very high doses.
Rare
- No significant rare side effects have been reported.
Contraindications
- Individuals taking nitrates for heart conditions or PDE5 inhibitors should consult a doctor before use.
Interactions
May potentiate the blood pressure-lowering effects.
Can lead to a significant drop in blood pressure.
Scientific Research
Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness
Supplementation with 8g of citrulline malate resulted in a significant increase in the number of repetitions performed and a 40% reduction in muscle soreness at 24 and 48 hours post-exercise.
Food Sources
Products With Citrulline DL-Malate
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.