Cat's Claw Extract (Uncaria tomentosa)
A powerful Amazonian vine used for immune support, inflammation, and joint health.
Also known as: Una de Gato • Uncaria tomentosa
Overview
Cat's claw (Uncaria tomentosa) is a woody vine native to the Amazon rainforest. It has been used by indigenous peoples for at least 2,000 years for inflammation, infections, and digestive issues. Its active compounds, pentacyclic oxindole alkaloids (POAs), have demonstrated significant immune-modulating and anti-inflammatory properties.
Key Benefits
Immune Support
POAs enhance white blood cell production and immune surveillance.
Anti-Inflammatory
Inhibits TNF-alpha and NF-kB inflammatory pathways.
Joint Health
Clinical trials show reduced pain and improved function in osteoarthritis.
DNA Repair
Studies show enhanced DNA repair mechanisms after supplementation.
Dosage & How to Take
250-500 mg standardized extract daily.
| Purpose | Dose | Notes |
|---|---|---|
| Immune support | 250-350 mg/day | Standardized to POAs |
| Joint health | 350-500 mg/day | For 8-12 weeks |
Best Time to Take
With meals.
With or Without Food
Yes, with food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Standardized Extract Capsules | Good | Precise POA dosing | Look for POA-standardized products. |
| Bark Tea | Moderate | Traditional use | Simmer inner bark for 15-20 minutes. |
| Tincture | Good | Quick absorption | Alcohol-based extract. |
Side Effects & Safety
Common
- Mild GI discomfort
- Dizziness at high doses
Rare
- Kidney issues with long-term high doses
Contraindications
- Pregnancy
- Autoimmune conditions
- Pre-surgery (anticoagulant effects)
- Organ transplant recipients
Interactions
May enhance anticoagulant effects.
May counteract immunosuppressive therapy.
May lower blood pressure.
Scientific Research
Cat's claw and osteoarthritis
RCT showed significant reduction in pain and improved joint function compared to placebo.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.