Avocado/Soybean Unsaponifiables
A natural vegetable extract that helps protect cartilage and support joint comfort.
Also known as: ASU
Overview
Avocado/Soybean Unsaponifiables (ASU) are a specific fraction of avocado and soybean oil that is not broken down (saponified) during digestion. This extract, typically in a one-third avocado to two-thirds soybean oil ratio, has been studied extensively in Europe for its benefits on joint health. ASU is believed to work by blocking pro-inflammatory chemicals, preventing the deterioration of synovial cells (which line the joints), and may help regenerate normal connective tissue.
Key Benefits
Cartilage Protection
Studies suggest ASU can reduce the breakdown of cartilage and promote its repair.
Reduces Need for NSAIDs
Long-term use has been shown to decrease the need for non-steroidal anti-inflammatory drugs in osteoarthritis patients.
Improves Joint Function
Helps to reduce pain and stiffness, leading to improved mobility and quality of life.
Dosage & How to Take
The standard and clinically effective dose is 300mg per day.
| Purpose | Dose | Notes |
|---|---|---|
| Osteoarthritis of the hip and knee | 300mg/day | Long-term use is recommended for best results. |
Best Time to Take
Can be taken at any time of day.
With or Without Food
Not necessary, can be taken with or without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Standardized ASU Extract (1:2 ratio) | Good | Long-term management of osteoarthritis symptoms. | This is the form used in clinical trials, often sold under the brand name Piascledine in Europe. |
Side Effects & Safety
Common
- Extremely well-tolerated.
Rare
- Mild digestive upset.
Contraindications
- Allergies to avocado or soy.
Interactions
Scientific Research
Avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial
ASU was effective in reducing pain and improving function in patients with knee and hip osteoarthritis, with a reduction in NSAID use.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.