Andrographis paniculata
A very bitter herb used in traditional medicine to treat infections and inflammation.
Also known as: King of Bitters • Kalmegh
Overview
Andrographis paniculata is a cornerstone of Ayurvedic and Traditional Chinese Medicine, revered for its potent immune-stimulating and anti-inflammatory properties. Its primary active compound, andrographolide, is responsible for its intense bitterness and therapeutic effects, particularly in treating upper respiratory infections.
Key Benefits
Treats Upper Respiratory Infections
Multiple clinical trials have shown Andrographis is effective in reducing the severity and duration of symptoms of the common cold and sinusitis.
Anti-inflammatory Effects
Andrographolides inhibit inflammatory pathways in the body, such as NF-kB, which can help reduce infection-related inflammation.
Immune Stimulation
Enhances the activity of immune cells, contributing to a more robust defense against pathogens.
Dosage & How to Take
For colds, a common dose is 400-600 mg of a standardized extract (containing 4-6% andrographolides) three times daily.
| Purpose | Dose | Notes |
|---|---|---|
| Common Cold | 1200-1800 mg/day (in divided doses) | For up to 7-10 days. The total daily andrographolide content is the key metric. |
Best Time to Take
Best taken with food.
With or Without Food
Yes, taking it with meals can help mitigate the bitterness and potential for gastric discomfort.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Standardized Extract | Good | Reliable and potent effects | Look for products standardized for andrographolide content, such as ParActin® or KalmCold®. |
Side Effects & Safety
Common
- Loss of appetite
- Diarrhea
- Vomiting
- Rash
- Headache
- Runny nose
- Fatigue
Rare
- Anaphylactic shock
- Elevated liver enzymes (with high doses or prolonged use).
Contraindications
- Pregnancy and breastfeeding. Autoimmune diseases (may overstimulate the immune system). May affect fertility in both men and women.
Interactions
May increase the risk of bleeding.
May decrease the effectiveness of these drugs.
May lower blood pressure, potentially enhancing the effect of antihypertensive drugs.
Scientific Research
Andrographis paniculata for the treatment of upper respiratory tract infections: A systematic review and meta-analysis
Andrographis was found to be beneficial and safe for relieving symptoms of acute respiratory tract infections.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.