Adiponectin
Metabolic hormone that regulates glucose and fatty acid metabolism.
Also known as: AdipoQ • Acrp30 • GBP28
Overview
Adiponectin is a protein hormone secreted by adipose tissue that plays a central role in regulating glucose levels, fatty acid oxidation, and insulin sensitivity. Higher adiponectin levels are associated with reduced risk of type 2 diabetes, cardiovascular disease, and metabolic syndrome. Supplements aim to support the body's natural adiponectin production.
Key Benefits
Insulin Sensitivity
Enhances insulin receptor signaling, improving glucose uptake and reducing insulin resistance.
Fat Oxidation
Stimulates fatty acid oxidation in muscle and liver, supporting healthy body composition.
Cardiovascular Protection
Anti-inflammatory and anti-atherogenic effects protect blood vessel walls and reduce plaque formation.
Anti-Inflammatory Action
Suppresses TNF-alpha and other pro-inflammatory cytokines, reducing systemic inflammation.
Dosage & How to Take
Adiponectin itself is not directly supplemented. Instead, compounds that boost adiponectin production are used, including berberine (500-1500mg), omega-3s (2-4g), and magnesium (200-400mg).
| Purpose | Dose | Notes |
|---|---|---|
| Metabolic support | Berberine 500mg 2-3x daily | Most studied adiponectin booster |
| Cardiovascular health | Omega-3s 2-4g daily | EPA+DHA increase adiponectin |
| General support | Magnesium 200-400mg daily | Correcting deficiency raises adiponectin |
Best Time to Take
Depends on the supporting supplement used
With or Without Food
Most adiponectin-boosting supplements are best taken with food
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Berberine Supplements | Medium | Direct adiponectin elevation | Most evidence-based approach |
| Omega-3 Fish Oil | High | Broad metabolic support | Also provides cardiovascular benefits |
| Organ Meat Extracts | Medium | Whole-food approach | Bone marrow contains adiponectin |
Side Effects & Safety
Common
- Varies by supporting supplement
Rare
- Hypoglycemia when combined with diabetes medications
Contraindications
- Consult doctor if on diabetes or cardiovascular medications
Interactions
Adiponectin-boosting supplements may enhance blood sugar lowering
Some statins may increase adiponectin levels, creating additive effects
Scientific Research
Adiponectin and Insulin Resistance
Low adiponectin levels strongly predicted development of type 2 diabetes in a 5-year prospective study
Berberine and Adiponectin
Berberine supplementation increased serum adiponectin by 28% in metabolic syndrome patients
Food Sources
Products With Adiponectin
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.