Acetyl-L-Carnitine (ALCAR)
An acetylated form of carnitine that crosses the blood-brain barrier for brain energy and neuroprotection.
Also known as: ALCAR • ALC • Acetylcarnitine
Overview
Acetyl-L-Carnitine (ALCAR) is the acetylated form of L-carnitine that readily crosses the blood-brain barrier. It supports mitochondrial energy production by transporting fatty acids into mitochondria and also donates its acetyl group for acetylcholine synthesis. ALCAR has demonstrated neuroprotective, antidepressant, and anti-aging properties in clinical research.
Key Benefits
Brain Energy
Transports fatty acids into brain mitochondria for energy production.
Acetylcholine Support
Donates acetyl groups for acetylcholine synthesis, supporting memory and learning.
Neuroprotection
Protects neurons from oxidative stress and supports nerve regeneration.
Mood Support
Meta-analysis shows antidepressant effects comparable to some medications.
Dosage & How to Take
500-2000 mg daily.
| Purpose | Dose | Notes |
|---|---|---|
| General cognitive support | 500-1000 mg/day | Morning dose |
| Mood/neuroprotection | 1000-2000 mg/day | Split into 2 doses |
Best Time to Take
Morning or early afternoon.
With or Without Food
Can be taken with or without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Capsules | Good | Standard use | Most convenient form. |
| Powder | Good | Flexible dosing | Slightly sour taste. |
Side Effects & Safety
Common
- Mild GI discomfort
- Fishy body odor at high doses
Rare
- Restlessness
- Insomnia
Contraindications
- Hypothyroidism (may interfere with thyroid hormone)
- Seizure disorders
Interactions
May reduce thyroid hormone effectiveness.
May have mild anticoagulant effects.
Scientific Research
ALCAR and depression
Meta-analysis of 12 RCTs showed ALCAR significantly reduced depressive symptoms, with effects comparable to established antidepressants.
Food Sources
Products With Acetyl-L-Carnitine (ALCAR)
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.